Aptamers against Polymeric Surfaces

Aptamers are short pieces of synthetic single stranded DNA or RNA, which are capable of binding like a selective molecular adhesive to a corresponding target molecule. The aptamer binding process is comparable to a key-lock pair and aptamers are often applied as therapeutics, diagnostics or biosensors.

The group of Prof. Lendlein searched for polymer binding aptamers, which are able to selectively bind to specific material surfaces. The challenge was the targeted isolation of the strongest binding aptamers from a starting molecule library with billions of different potential ligands. [...]

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