WEB Screening Solubility-Enhancing Coformers in Amorphous Solid Dispersions: a Group Contribution based Miscibility Method
The thermodynamic behavior of binary mixtures such as polymer blends, amorphous solid dispersions, cocrystal and salts, and etc. are of great interest in many active pharmaceutical ingredient applications where low solubility/bioavailability of drugs is an issue the pharma industry faced. Screening solubility-enhancing coformers and/or excipients for drug(s) of interest is therefore remained major challenge. A high throughput method for (1) screening of available materials and/or (2) design of possible candidates to be synthesized for each drug is of crucial importance. To address this challenge, here, a systematically improvable method is examined against its performance for nine different drug-polymer pairs commonly used in amorphous solid dispersion technology including dipyridamole, cinnarizine, itraconazole as drugs and polystyrene, polyvinyl pyrrolidone, polyacrylic acid as polymers. The other applications of reported code may include organic solvent selection, cocrystal and salt screening, and etc.
Code availability: sites.google.com/site/miladasgarpour/Posts/Archived/ASDx
|Category||Short file description||File description||File Size|
|Poster||Updated Poster presentation PDF||I fixed the link in the abstract.||471 KB||Download|
|Poster||Updated Poster presentation PDF||I fixed the link in the abstract.||374 KB||Download|